{"id":10162,"date":"2025-12-27T17:55:08","date_gmt":"2025-12-27T16:55:08","guid":{"rendered":"https:\/\/knowipedia.com\/index.php\/2025\/12\/27\/ubr5\/"},"modified":"2025-12-27T17:55:08","modified_gmt":"2025-12-27T16:55:08","slug":"ubr5","status":"publish","type":"post","link":"http:\/\/knowipedia.com\/index.php\/2025\/12\/27\/ubr5\/","title":{"rendered":"UBR5"},"content":{"rendered":"<div class=\"aw-split-readmore\"><a id=\"aw-readmore\"><\/a><\/div>\n<p>**UBR5**<\/p>\n<p>**Definition**<br \/>\nUBR5 is a human gene that encodes an E3 ubiquitin-protein ligase involved in protein ubiquitination, a process critical for regulating protein degradation and cellular signaling.<\/p>\n<p>**Article**<\/p>\n<p>### Overview<br \/>\nUBR5, also known as EDD1, is a gene located on chromosome 8q22.3. It encodes an E3 ubiquitin ligase enzyme that plays a significant role in targeting proteins for ubiquitination, thereby marking them for proteasomal degradation or modulating their activity.<\/p>\n<p>### Function<br \/>\nThe UBR5 protein participates in various cellular processes including DNA damage response, cell cycle regulation, and transcriptional control. By attaching ubiquitin molecules to substrate proteins, UBR5 influences protein stability and function, impacting cell proliferation and survival.<\/p>\n<p>### Clinical Significance<br \/>\nAlterations in UBR5 expression or function have been implicated in cancer development and progression. Its role in maintaining genomic stability makes it a potential target for therapeutic intervention in oncology.<\/p>\n<p>**Meta Description**<br \/>\nUBR5 is a human gene encoding an E3 ubiquitin ligase involved in protein regulation, DNA damage response, and cell cycle control. It is significant in cancer research due to its role in cellular stability.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>**UBR5** **Definition** UBR5 is a human gene that encodes an E3 ubiquitin-protein ligase involved in protein ubiquitination, a process critical for regulating protein degradation and cellular signaling. **Article** ### Overview UBR5, also known as EDD1, is a gene located on chromosome 8q22.3. It encodes an E3 ubiquitin ligase enzyme that plays a significant role in <a class=\"moretag\" href=\"http:\/\/knowipedia.com\/index.php\/2025\/12\/27\/ubr5\/\">Czytaj dalej<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5872,5871,1],"tags":[11363],"class_list":["post-10162","post","type-post","status-publish","format-standard","hentry","category-biology","category-chemistry","category-general","tag-ubr5"],"_links":{"self":[{"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/posts\/10162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/comments?post=10162"}],"version-history":[{"count":0,"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/posts\/10162\/revisions"}],"wp:attachment":[{"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/media?parent=10162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/categories?post=10162"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/knowipedia.com\/index.php\/wp-json\/wp\/v2\/tags?post=10162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}