**PIEZO2**
**Definition**
PIEZO2 is a gene that encodes a mechanosensitive ion channel protein involved in the transduction of mechanical stimuli into cellular signals. It plays a critical role in the sensation of touch and proprioception in humans and other animals.
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**PIEZO2**
PIEZO2 is a mechanosensitive ion channel protein encoded by the PIEZO2 gene located on chromosome 18 in humans. It belongs to the PIEZO family of ion channels, which are large transmembrane proteins that respond to mechanical forces by allowing the flow of cations across the cell membrane. This process is essential for converting mechanical stimuli into electrical signals within sensory neurons.
### Function
PIEZO2 is primarily expressed in sensory neurons and specialized cells involved in mechanotransduction. It is crucial for the detection of light touch, vibration, and proprioceptive feedback, which informs the brain about body position and movement. The protein forms a trimeric complex that opens in response to membrane tension, enabling the influx of calcium and other ions.
### Physiological and Clinical Significance
Mutations in the PIEZO2 gene have been linked to several rare genetic disorders characterized by impaired touch sensation and proprioception, such as distal arthrogryposis and Gordon syndrome. Research on PIEZO2 has expanded understanding of mechanosensation and holds potential for developing treatments for sensory dysfunctions.
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**Meta Description**
PIEZO2 is a mechanosensitive ion channel essential for touch sensation and proprioception. It plays a key role in converting mechanical stimuli into neural signals in sensory neurons.