**KCNK17**
**Definition**
KCNK17 is a human gene that encodes a member of the two-pore domain potassium channel family, involved in regulating cellular electrical activity.
**Article**
### Overview
KCNK17 (Potassium Channel, Two Pore Domain Subfamily K, Member 17) is a gene that encodes a potassium channel protein contributing to the maintenance of the resting membrane potential in cells. It belongs to the family of two-pore domain potassium (K2P) channels, which are characterized by their unique structure containing two pore-forming domains per subunit.
### Structure and Function
The KCNK17 protein forms background potassium channels that allow potassium ions to passively flow across the cell membrane, helping to stabilize the electrical excitability of cells. These channels are typically open at rest and contribute to setting the resting membrane potential, influencing processes such as neuronal signaling and muscle contraction.
### Expression and Physiological Role
KCNK17 is expressed in various tissues, including the brain and heart, where it plays a role in modulating cellular excitability and protecting cells from excessive depolarization. Its activity can be regulated by factors such as pH and mechanical stretch, highlighting its importance in adapting cellular responses to environmental changes.
### Clinical Significance
While research on KCNK17 is ongoing, alterations in K2P channels have been implicated in neurological disorders and cardiac dysfunctions, suggesting that KCNK17 may have potential relevance in these conditions.
**Meta Description**
KCNK17 is a human gene encoding a two-pore domain potassium channel involved in regulating cellular electrical activity and maintaining resting membrane potential. It plays a role in neuronal and cardiac function.