**CDKN2D**
**Definition**
CDKN2D (Cyclin-Dependent Kinase Inhibitor 2D) is a human gene that encodes a protein involved in regulating the cell cycle. It functions as a cyclin-dependent kinase inhibitor, playing a critical role in controlling cell proliferation.
**Article**
### Overview
CDKN2D is a member of the INK4 family of cyclin-dependent kinase inhibitors. The protein encoded by this gene specifically inhibits CDK4 and CDK6, enzymes essential for progression through the G1 phase of the cell cycle. By binding to these kinases, CDKN2D prevents their association with D-type cyclins, thereby halting cell cycle progression and acting as a tumor suppressor.
### Function
The primary function of CDKN2D is to regulate cell division by controlling the activity of cyclin-dependent kinases. This regulation ensures proper cell cycle checkpoints and prevents uncontrolled cell growth, which is a hallmark of cancer development.
### Clinical Significance
Alterations or mutations in CDKN2D have been implicated in various cancers, highlighting its role in tumor suppression. Understanding its function contributes to insights into cell cycle dysregulation in oncogenesis.
**Meta Description**
CDKN2D is a gene encoding a cyclin-dependent kinase inhibitor that regulates cell cycle progression. It plays a key role in controlling cell proliferation and acts as a tumor suppressor.