**ZEB2-AS1**
**Definition**
ZEB2 antisense RNA 1 (ZEB2-AS1) is a long non-coding RNA (lncRNA) involved in the regulation of gene expression, particularly influencing the epithelial-mesenchymal transition (EMT) process by modulating the ZEB2 gene.
**Article**
### Overview
ZEB2-AS1 is a long non-coding RNA transcribed from the antisense strand of the ZEB2 gene locus. It plays a regulatory role in gene expression without encoding a protein. This lncRNA is known to affect the stability and translation of ZEB2 mRNA, thereby impacting cellular processes such as differentiation, migration, and invasion.
### Biological Function
ZEB2-AS1 contributes to the epithelial-mesenchymal transition by enhancing ZEB2 expression, a transcription factor critical for EMT. EMT is a key mechanism in development, wound healing, and cancer metastasis. Through its regulatory effects, ZEB2-AS1 influences tumor progression and metastasis in various cancers.
### Clinical Significance
Altered expression of ZEB2-AS1 has been observed in multiple cancer types, where it is often associated with poor prognosis. Its role in promoting EMT makes it a potential target for therapeutic intervention in oncology.
**Meta Description**
ZEB2-AS1 is a long non-coding RNA that regulates the ZEB2 gene and influences epithelial-mesenchymal transition. It plays a significant role in cancer progression and metastasis.