**Saruplase**
**Definition**
Saruplase is a fibrinolytic agent used as a thrombolytic drug to dissolve blood clots in the treatment of acute myocardial infarction and other thromboembolic conditions.
**Article**
## Overview
Saruplase is a recombinant plasminogen activator that promotes the breakdown of fibrin clots by converting plasminogen to plasmin. It is primarily employed in emergency settings to restore blood flow in patients experiencing acute myocardial infarction (heart attack) and other conditions caused by obstructive blood clots.
## Mechanism of Action
Saruplase selectively binds to fibrin within a thrombus, activating plasminogen to plasmin, which then degrades the fibrin matrix. This process leads to clot dissolution and reperfusion of the affected blood vessels.
## Clinical Use
Administered intravenously, saruplase is used in hospitals under strict medical supervision. Its efficacy and safety profile are comparable to other thrombolytic agents, though its use depends on patient-specific factors and clinical guidelines.
## Side Effects and Precautions
Common side effects include bleeding complications, which can be severe. Contraindications include active internal bleeding, recent surgery, or hemorrhagic stroke. Careful patient assessment is essential before administration.
**Meta Description**
Saruplase is a thrombolytic drug used to dissolve blood clots in acute myocardial infarction. It works by activating plasminogen to break down fibrin clots.