WRAP53

Definition: **
WRAP53 (WD40-encoding RNA Antisense to p53) is a gene that encodes a protein involved in the regulation of the tumor suppressor p53 and the maintenance of cellular structures such as Cajal bodies. It plays a critical role in RNA processing and DNA repair.

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**WRAP53**

**Definition:**
WRAP53 (WD40-encoding RNA Antisense to p53) is a gene that encodes a protein involved in the regulation of the tumor suppressor p53 and the maintenance of cellular structures such as Cajal bodies. It plays a critical role in RNA processing and DNA repair.

**Article:**

### Overview
WRAP53 is a gene located on human chromosome 17 that produces a protein essential for various cellular functions. The WRAP53 protein is known for its role in stabilizing the p53 tumor suppressor mRNA, thereby influencing p53 protein levels and activity.

### Function
WRAP53 is involved in the biogenesis and maintenance of Cajal bodies, nuclear suborganelles important for the maturation of small nuclear ribonucleoproteins (snRNPs). Additionally, WRAP53 participates in the DNA damage response by facilitating the recruitment of repair factors to sites of DNA breaks.

### Clinical Significance
Mutations or dysregulation of WRAP53 have been linked to diseases such as dyskeratosis congenita and various cancers, highlighting its importance in genomic stability and cell cycle regulation.

**Meta Description:**
WRAP53 is a gene encoding a protein that regulates p53 tumor suppressor activity and maintains Cajal bodies, playing a key role in RNA processing and DNA repair. Its dysfunction is associated with genetic disorders and cancer.