**Hemoglobin E**
**Definition**
Hemoglobin E (HbE) is an abnormal variant of hemoglobin caused by a genetic mutation in the beta-globin gene. It is one of the most common hemoglobin variants worldwide, particularly prevalent in Southeast Asia.
**Overview**
Hemoglobin E results from a single point mutation in the beta-globin gene, leading to the substitution of lysine for glutamic acid at position 26. This mutation affects the structure and function of hemoglobin, often causing mild anemia or no symptoms in heterozygous individuals. However, when inherited alongside other hemoglobinopathies, such as beta-thalassemia, it can lead to more severe blood disorders. Diagnosis is typically made through hemoglobin electrophoresis or genetic testing. Management depends on the severity of symptoms and may require regular monitoring or treatment for anemia.
**META_DESCRIPTION**
Hemoglobin E is a common genetic variant of hemoglobin caused by a mutation in the beta-globin gene, prevalent in Southeast Asia. It can cause mild anemia or more severe conditions when combined with other hemoglobin disorders.